Affiliation:
1. Azerbaijan Medical University
Abstract
Aim. To explore clinical diagnostical criteria of hypergonadotropic hypogonadism in patients with hyperandrogenia in reproductive period. Material and methods. 21 women with hyperandrogenia and hypergonadotropic hypogonadism were examined (basic qroup). Comperative qroup was presented by 20 practically healthy women of reproductive age. The following indicators were investigated family history, the severity of hirsutism, blood levels of folliculostimulating (FSH), luteinized (LH), thyroid stimulating (TSH) hormons, the ratio of LH/FSH, prolactin, cortizol, 17-oxyprogesterone (17-OP), dehydroepiandrosterone sulfate (DHEA-S), androstentione, total testosterone, free triyoitironin (T2), thyroxine (T4), estrone (E1), estradiol (E2), sex hormone binding globuline (SHBG), antimullerian hormone (AMH). Results. There was confirmed that patients of reproductive age with hypergonadotropic hypogonadism with hyperandrogenia have significant elevation of FSH, LH, E1, An, K, 17-OP, DHEA-S, free testosterone leveles, and decreasing of E2, SHBG and AMH livels. Timely diagnosis of hypergonadotropic hypogonadism significantly reduces the risk of premature ovarian failure, and increases probability of spontaneous pregnancy.
Publisher
Medical Informational Agency Publishers
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