The influence of thrombophilia and obesity on the risk of venous thrombosis

Author:

Belenkov Y.1,Golub Anna V.1,Popova L.1,Shelest E.1,Patrushev L.2,Kondratieva T.1,Aksenova M.1,Hlevchuk T.1

Affiliation:

1. I.M. Sechenov First Moscow State Medical University (Sechenov University )

2. M.M. Shemyakin & Yu.A.Ovchinnikov Institute of Bioorganic Chemistry

Abstract

Risk factors of venous thromboembolism are acquired factors such as obesity, hormonal contraceptives, immobilization, and thrombophilia. Their combination leads to an increased risk of venous thrombosis. Objective: The aim of the study was to investigate effect of high BMI on the risk of venous thrombosis in patients with thrombophilia. Material and methods. We examined 96 patients with thrombophilia (mean age 51.61 years, 42 women and 54 men) and 73 patients without mutations (mean age 41.12 years, 17 men and 56 women) with different BMI. The first group involved 31 patients with venous thromboembolism, the second group included 15 patients. Results. The combination of BMI > 25 kg/m2 and thrombophilia influences the risk of venous thromboembolism.

Publisher

Medical Informational Agency Publishers

Subject

General Medicine

Reference15 articles.

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2. Cohen A.T., Agnelli G., Anderson F.A. et al. Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality. Thromb. Haemost. 2007; 98(4): 756—64.

3. Russian Consensus «Prevention of Postoperative Venous Thromboembolic Complications». Moscow: Russian Association of Phlebology; 2000: 8. (in Russian)

4. Savel'ev V.S., Chazov E.I. Russian clinical recommendations for diagnosis, treatment and prophylaxis venous thromboembolic complications. Flebologiya. 2010;4(2): 2—37. (in Russian)

5. Bokarev I.N., Popova L.V. Modern problems of thrombosis of arteries and veins. Prakticheskaya meditsina. 2014; 6(82): 13—7. (in Russian)

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