BIOCHEMICAL PREDICTORS OF CARTILAGINOUS TISSUE METABOLIC DISORDERS FOR EARLY OSTEOARTHROSIS EVIDENCE DIAGNOSTICS-Reference-Cited by-同舟云学术

BIOCHEMICAL PREDICTORS OF CARTILAGINOUS TISSUE METABOLIC DISORDERS FOR EARLY OSTEOARTHROSIS EVIDENCE DIAGNOSTICS

Published:2020-03-15 Issue:3 Volume:65 Page:155-162
ISSN:0869-2084
Container-title:Russian Clinical Laboratory Diagnostics
language:
Short-container-title:RCLD

Author:

Gladkova E. V.¹^ORCID

Affiliation:

1. The Fundamental, Clinical and Experimental Research Department; Scientific Research Institute of Traumatology, Orthopedics and Neurosurgery of the Federal State Budgetary Educational Institution of Higher Education Saratov State Medical University n.a. V.I. Razumovsky of the Ministry of Public Health of the Russian Federation

Abstract

The complete laboratory and clinical instrumental examination was conducted, it included serum COMP test, circadian excretion of type II collagen C-terminal telopeptides Urine CartiLaps (СТХ II) and Т2 relaxometry in 29 patients of both sexes of the main group with early (0-I) X-ray osteoarthrosis stages, 30 subjects of comparison group with no X-ray osteoarthrosis evidences aged 44.7±5.9 years and 25 healthy subjects aged 26.3±2.6 years of the control group. The increase (р<0,05) of COMP and Urine CartiLaps levels as well as the increase of Т2 relaxation signal was found at early osteoarthrosis evidences. It was proven that there was (р<0.01) a connection (R=0.8) between COMP and Urine CTX II levels as well as (р<0.05) results of Т2 relaxometry (R=0.8). It was proven that collagen anisotropy and formation of chondromalacia areas as Т2 relaxometry showed in patients with early OA evidences were connected with accumulation of serum COMP and increase of type II collagen circadian renal excretion. The combination of laboratory and radiological methods of articular hyaline cartilage assessment may be used for finding early osteoarthrosis stages.

Publisher

EKOlab

Subject

Biochemistry (medical),Medical Laboratory Technology,General Medicine

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