THE PROBLEM OF DECOLONIZATION OF STAPHYLOCOCCUS AUREUS NASAL CARRIERS FROM THE MICROBIOLOGIST’S POINT OF VIEW (REVIEW OF LITERATURE)-Reference-Cited by-同舟云学术

THE PROBLEM OF DECOLONIZATION OF STAPHYLOCOCCUS AUREUS NASAL CARRIERS FROM THE MICROBIOLOGIST’S POINT OF VIEW (REVIEW OF LITERATURE)

Published:2019-11-15 Issue:11 Volume:64 Page:693-699
ISSN:0869-2084
Container-title:Russian Clinical Laboratory Diagnostics
language:
Short-container-title:RCLD

Author:

Melnikov V. G.¹^ORCID,Villena J.²,Kombarova S. Yu.¹

Affiliation:

1. G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology of Rospotrebnadzor

2. Immunobiotics Research Group, Reference Centre for Lactobacilli (CERELA-CONICET)

Abstract

Staphylococcus aureus asymptomatically persists on the nasal mucosa, and also causes serious diseases in carriers (endogenous infection) and in patients in a hospital (nosocomial infection). Decolonization of nasal carriers of S. aureus is an important measure aimed at reducing the incidence of staphylococcal infections. Carriage is a form of nasal dysbiosis, therefore, the effectiveness of antibiotics for the decolonization of carriers, by definition, is low. The review discusses the prospects of using probiotics to restore the nasal microbiota. The commercial production of nasal probiotics has not yet been established, but developments in this direction are being carried out in different countries. The experimental substantiation of the possibility of using corynebacteria and other representatives of the nasal microbiota for the decolonization of staphylococcal carriers is presented, as well as the authors’ ideas on how to improve the methods of microbial therapy. In particular, it was proposed to use biofilm probiotics, autoprobiotics, and autovaccines for this purpose.

Publisher

EKOlab

Subject

Biochemistry, medical,Medical Laboratory Technology,General Medicine

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