DIAGNOSTICS VALUE AND REGULATORY FUNCTIONS OF PROINSULIN

Author:

Poteryaeva O. N.1,Usynin I. F.1

Affiliation:

1. Institute of Biochemistry, Federal Research Center of Fundamental and Translation Medicine

Abstract

Proinsulin is one of the indicators reflecting the functional activity of the pancreas. In insulin-independent diabetes mellitus the ratio proinsulin / insulin is increased. The review examined the causes of hyperproinsulinemia and the diagnostic value of proinsulin in patients with diabetes mellitus type 1 and 2. The role of proinsulin in the regulation of metabolic pathways and the preservation of the functional activity of cells under physiological conditions, during aging and during pathological processes is discussed. Studies in these areas justify the inclusion of proinsulin in the superfamily of signaling factors. The neuroprotective activity of proinsulin and its potential as a therapeutic tool for neurodegenerative diseases and retinal dystrophy are considered.

Publisher

EKOlab

Subject

Biochemistry, medical,Medical Laboratory Technology,General Medicine

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The role of C-peptide in regulation of the insulin signaling system (systematic review);Сибирский научный медицинский журнал;2021-03-04

2. Molecular Mechanisms of Action and Physiological Effects of the Proinsulin C-Peptide (a Systematic Review);Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry;2021-01

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