Single-molecule fluorescence imaging of RalGDS on cell surfaces during signal transduction from Ras to Ral

Author:

Yoshizawa Ryo12,Umeki Nobuhisa1,Yanagawa Masataka1,Murata Masayuki2,Sako Yasushi1

Affiliation:

1. Cellular Informatics Lab., RIKEN

2. Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo

Publisher

Biophysical Society of Japan

Subject

General Medicine

Reference16 articles.

1. [1] Guin, S. & Theodorescu, D. The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer. Acta Pharmacol. Sin. 36, 291–297 (2015).

2. [5] Mochizuki, N., Yamashita, S., Kurokawa, K., Ohba, Y., Nagai, T., Miyawaki, A., et al. Spatio-temporal images of growth-factor-induced activation of Ras and Rap1. Nature 411, 1065–1068 (2001).

3. [6] Lu, S., Jang, H., Muratcioglu, S., Gursoy, A., Keskin, O., Nussinov, R., et al. Ras Conformational Ensembles, Allostery, and Signaling. Chem. Rev. 116, 6607–6665 (2016).

4. [10] Takaya, A., Ohba, Y., Kurokawa, K. & Matsuda, M. RalA activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney cells. Mol. Biol. Cell 15, 2549–2557 (2004).

5. [11] Katz, M., Amit, I. & Yarden, Y. Regulation of MAPKs by growth factors and receptor tyrosine kinases. Biochim. Biophys. Acta 1773, 1161–1176 (2007).

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