Structural and functional properties of Grb2 SH2 dimer in CD28 binding

Author:

Hosoe Yuhi1,Numoto Nobutaka2,Inaba Satomi13,Ogawa Shuhei4,Morii Hisayuki5,Abe Ryo46,Ito Nobutoshi2,Oda Masayuki1

Affiliation:

1. Graduate School of Life and Environmental Sciences, Kyoto Prefectural University

2. Medical Research Institute, Tokyo Medical and Dental University

3. Research & Utilization Division, Japan Synchrotron Radiation Research Institute

4. Research Institute for Biomedical Sciences, Tokyo University of Science

5. College of Liberal Arts and Sciences, Tokyo Medical and Dental University

6. Present address: Strategic Innovation and Research Center, Teikyo University

Publisher

Biophysical Society of Japan

Subject

General Medicine

Reference12 articles.

1. [8] Ogawa, S., Watanabe, M., Sakurai, Y., Inutake, Y., Watanabe, S., Tai, X., et al. CD28 signaling in primary CD4+ T cells: identification of both tyrosine phosphorylation-dependent and phosphorylation-independent pathways. Int. Immunol. 25, 671–681 (2013).

2. [9] Higo, K., Ikura, T., Oda, M., Morii, H., Takahashi, J., Abe, R., et al. High resolution crystal structure of the Grb2 SH2 domain with a phosphopeptide derived from CD28. PLoS One 8, e74482 (2013).

3. [10] Inaba, S., Numoto, N., Ogawa, S., Morii, H., Ikura, T., Abe, R., et al. Crystal structures and thermodynamic analysis reveal distinct mechanisms of CD28 phosphopeptide binding to the Src homology 2 (SH2) domains of three adaptor proteins. J. Biol. Chem. 292, 1052–1060 (2017).

4. [11] Rahuel, J., Gay, B., Erdmann, D., Strauss, A., Garcia-Echeverría, C., Furet, P., et al. Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode. Nat. Struct. Biol. 3, 586–589 (1996).

5. [13] Rahuel, J., García-Echeverría, C., Furet, P., Strauss, A., Caravatti, G., Fretz, H., et al. Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands. J. Mol. Biol. 279, 1013–1022 (1998).

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