Charge block-driven liquid-liquid phase separation: A mechanism of how phosphorylation regulates phase behavior of disordered proteins
Author:
Affiliation:
1. Faculty of Integrated Human Science, Kyoto University
2. Graduate School of Biostudies, Kyoto University
3. Center for Living Systems Information Science (CeLiSIS), Kyoto University
Publisher
Biophysical Society of Japan
Link
https://www.jstage.jst.go.jp/article/biophysico/21/2/21_e210012/_pdf
Reference26 articles.
1. [1] Ardito, F., Giuliani, M., Perrone, D., Troiano, G., Lo Muzio, L. The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy. Int. J. Mol. Med. 40, 271–280 (2017). https://doi.org/10.3892/ijmm.2017.3036
2. [2] Horn, H., Schoof, E. M., Kim, J., Robin, X., Miller, M. L., Diella, F., et al. KinomeXplorer: An integrated platform for kinome biology studies. Nat. Methods 11, 603–604 (2014). https://doi.org/10.1038/nmeth.2968
3. [3] Jiang, Z. G., McKnight, C. J. A phosphorylation-induced conformation change in dematin headpiece. Structure (London, England: 1993) 14, 379–387 (2006). https://doi.org/10.1016/j.str.2005.11.007
4. [4] Hamelberg, D., Shen, T., McCammon, J. A. Phosphorylation effects on cis/trans isomerization and the backbone conformation of serine-proline motifs: accelerated molecular dynamics analysis. J. Am. Chem. Soc. 127, 1969–1974 (2005). https://doi.org/10.1021/ja0446707
5. [5] Yamazaki, H., Yoshimura, S. H. Molecular mechanism of “Charge Block-driven” liquid-liquid phase separation and its regulation by phosphorylation. SEIBUTSU BUTSURI 63, 153–156 (2023). https://doi.org/10.2142/biophys.63.153
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