Characterization of compounds in Cornelian cherry (Cornus mas L.) and its effect on interior milieu in ZDF

Abstract

The risk of type 2 Diabetes mellitus is constantly increasing and therefore it is necessary to seek effective and new therapies. Cornelian cherry (Cornus mas L.) presents an opportunity in an alternative for treatment of type 2 Diabetes mellitus due its high antioxidant effects. The objective of the study was to assess the effect of Cornelian cherry pulp and stone on ZDF rats, which are suitable biological model for type 2 diabetes. ZDF rats received Cornelian cherry in three doses (1500, 2000 mg kg-1 body weight of the pulp and 250 mg kg-1 body weight of the stone) using the sterile oral rodent gavage for 4 months. Blood glucose, insulin, antioxidant activity and compounds in Cornelian cherry were determined to investigate the effects. Cornelian cherry stone significantly decreased affected blood glucose levels in ZDF rats when compared to the untreated control group. Total polyphenols and phenolic acids had significantly higher values in Cornelian cherry stone against pulp. Also, high concentrations of the anthocyanins were determined in the pulp. The results suggest that Cornelian cherry stone would potentially provide promising source of natural antioxidants and use in the management of Diabetes mellitus.