Author:
Mu Ning,Yang Chuan-Yan,Ma Kang,Quan Yu-Lian,Wang Shi,Lai Ying,Li Fei,Wang Yu-Ye,Chen Tu-Nan,Xu De-Gang,Feng Hua, ,
Abstract
Terahertz wave is an electromagnetic wave, whose wavelength is located between microwave wavelength and infrared wavelength. Based on low ionization and fingerprint characteristics, it has great potential applications in biomedical field, especially in the intraoperative localization and qualitative diagnosis of tumors. Glioma is the most urgent tumor for positioning qualitative diagnosis. Owing to its invasiveness and heterogeneity, it is easy to relapse after resection and has a significant influence on the nerve function of adjacent brain regions. Therefore, rapid determination of tumor boundary and pathological characteristics is an important prerequisite for accurate diagnosis, treatment and clinical research of glioma. Here, we summarize the biophysical technology of glioma diagnosis, and expound the new technique of terahertz wave and its research results in diagnosis of glioma. Furthermore, based on the research progress of integrated diagnosis of glioma histopathology and molecular pathology, we propose a hypothesis that different molecular subtypes of tumor tissue may have a consistent 'differential terahertz wave protein composition' of terahertz tumor subtype recognition mechanism. Finally, combining the biological characteristics of brain tissue and the potential of glioma marker detection in body fluids, we discuss the clinical application model and prospects of terahertz technologies in glioma detection.
Publisher
Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences
Subject
General Physics and Astronomy
Reference159 articles.
1. Wen P Y, Kesari S 2008 New Engl. J. Med. 359 492
2. Coons S W, Johnson P C, Scheithauer B W, Yates A J, Pearl D K 1997 Cancer 79 1381
3. Qi N, Zhang Z Y, Xiang Y H 2013 Spectrosc. Spectral Anal. 33 2064
齐娜, 张卓勇, 相玉红 2013 光谱学与光谱分析 33 2064
4. Liu H, Xu D G, Yao J Q 2008 Acta Phys. Sin. 57 5662
刘欢, 徐德刚, 姚建铨 2008 物理学报 57 5662
5. Schirmer M, Fujio M, Minami M, Miura J, Araki T, Yasui T 2010 Biomed. Opt. Express 1 354
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献