Ultrasonic enhancement of interaction between liposome and cell

Abstract

The interaction between liposomes and cells under ultrasound exposure was theoretically and experimentally studied. We experimentally developed liposomes containing fluorescent materials, and measured the efficiency of drug delivery in a suspension containing liposomes and cells under 1 MHz ultrasound excitation for 40 s. Results demonstrated that the sonicated samples were superior to the control group （without ultrasound） in absorbing fluorescent materials and the capacity was improved by 8.78% under the excitation of ultrasound at an acoustic pressure amplitude of 0.24 MPa. Finally, the potential mechanisms of ultrasound enhancement was discussed with respect to the changes of velocity and diameter of liposomes induced by ultrasound.