Nonspecific adsorption of charged mesoporous nanoparticles on supported thiol/lipid hybrid bilayers

Abstract

Mesoporous silica nanoparticles (MSN) with cationic and anionic surface charges were synthesized, Their adsorption behaviors to the supported lipid membranes at different pH values were also studied using QCM-D. We found that NH2-MSN could be adsorbed onto the membrane at pH values from 4 to 8, while the adsorption of COOH-MSN onto the membrane could not occur due to its charge being always the same as that of the membrane at any pH values. These results might provide the information for understanding and predicting the interactions between nanoparticles and cell membranes, and could be effectively used in drug delivery systems and disease treatment.