Abstract
Palindromes are two groups of identical sequences which join each other in inverted direction. The palindrome mediated genomic instability contributes to a diverse group of genomic rearrangements like translocations, deletions, and amplifications. Palindrome involve in translocation have AT richness (PATRRs) and the best suited examples of this is t(11;22) translocation. PATRR22 is a hotspot of palindrome mediated translocation. Several molecular methods involve in identification of various PATRRs which modulate translocation by mechanism of double strand break (DSB), especially in gametogenesis. However, the precise mechanism of DSB, cloning of critical translocating factor PATRR22, enzymatic pathways and timing involved in formation of PATRRs translocations in gametogenesis is still undiagnosed.