Antileishmanial Compounds from Moringa oleifera Lam.

Author:

Kaur Amandeep1,Kaur Preet Kamal2,Singh Sushma2,Singh Inder Pal1

Affiliation:

1. Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar, Punjab 160062, India. Fax: +91-172-2214692.

2. Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar, Punjab 160062, India

Abstract

The antileishmanial activity of extracts and phytoconstituents of Moringa oleifera Lam: was investigated in vitro against promastigotes of Leishmania donavani. The 70%ethanolic extract of roots and the methanolic extract of leaves showed moderate inhibitory activity with IC50 values of 83:0 μg/ml and 47:5 μg/ml, respectively. Antileishmanial activity of the methanolic extract of leaves increased upon fractionation, as its ethyl acetate fraction was found to be more active with an IC50 value of 27:5 mg=ml. The most active antileishmanial compound niazinin, a thiocarbamate glycoside isolated from this fraction, showed an IC50 value of 5:25 mM. Results presented in this study indicate that extracts from M. oleifera may be developed as an adjuvant therapy for the treatment of leishmaniasis.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

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