Cytotoxic Polyacetylenes from the Red Sea Sponge Siphonochalina siphonella-Reference-Cited by-同舟云学术

Cytotoxic Polyacetylenes from the Red Sea Sponge Siphonochalina siphonella

Published:2014-04-01 Issue:3-4 Volume:69 Page:117-123
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Ayyad Seif-Eldin N.¹²,Angawy Rihab¹,Alarif ³⁴,Saqer Esraa A.¹,Badria Farid A.⁵

Affiliation:

1. Department of Chemistry, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah 21589, Saudi Arabia. Fax: +966 2 6951599.

2. Permanent address: Department of Chemistry, Faculty of Science, Damietta University, Damietta, Egypt

3. Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, P. O. Box 80207, Jeddah 21589, Saudi Arabia

4. Forensic Chemistry Laboratory at Mansoura, Ministry of Justice, Mansoura, Egypt

5. Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt

Abstract

Two new polyacetylenes, callyspongenol-D (1) and callyspongendiol (2), the known polyacetylene dehydrosiphonochalynol (3), and the known triterpenoid sipholenol-A (4) were isolated from the Red Sea sponge Siphonochalina siphonella. Their chemical structures were elucidated on the basis of spectroscopic analyses. The cytotoxicity of the isolated compounds towards the human mammary carcinoma cell line MCF-7 was determined by the lactate dehydrogenase (LDH) assay, and compounds 4 and 1 were found to be the most toxic of the four, with IC50 values of 8.8 and 11:7 mM, respectively.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.5560/znc.2013-0088/pdf

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