Synthesis and Antitumor Activity of Some N2-(Thien-3-yl)amidrazones-Reference-Cited by-同舟云学术

Synthesis and Antitumor Activity of Some N2-(Thien-3-yl)amidrazones

Published:2014-06-02 Issue:7 Volume:69 Page:811-816
ISSN:1865-7117
Container-title:Zeitschrift für Naturforschung B
language:en
Short-container-title:

Author:

Abadleh Mohammed M.¹,El-Abadelah Mustafa M.²,Sabri Salim S.²,Mohammed Hanan H.²,Zihlif Malek A.³,Voelter Wolfgang⁴

Affiliation:

1. College of Pharmacy, Taibah University, Al Madinah Almonawarrah, 41477, Saudia Arabia

2. Chemistry Department, Faculty of Science, The University of Jordan, Amman 11942, Jordan

3. Department of Pharmacology, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan

4. Interfakultäres Institut für Biochemie, Universität Tübingen, Hoppe-Seyler-Straße 4, 72076 Tübingen, Germany

Abstract

6a A set of new N2-(thien-3-yl)amidrazones (-h) incorporating N-piperazines and related congeners has been synthesized by reacting the hydrazonoyl chloride 4(derived from 3-aminothiophene- 2-carboxylate) with the appropriate sec-cyclic amine. The antitumor activity of these compounds was evaluated on breast cancer (MCF-7) and leukemic (K562) cell lines by a cell viability assay utilizing the tetrazolium dye (MTT). The amidrazone 6d encompassing the N-piperazine moiety, was the most active against MCF-7 and K562 with IC50 of 7.28 and 9:91 μM, respectively.

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

Link

https://www.degruyter.com/document/doi/10.5560/znb.2014-4062/pdf

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis and Antitumor Activity of Some New N1-(8-fluoro-4-oxoquinolin-5-yl)amidrazones;Current Organic Synthesis;2024-12

2. A Review of the Biological Activity of Amidrazone Derivatives;Pharmaceuticals;2022-09-30

3. An Integrative Informatics Approach to Explain the Mechanism of Action of N1-(Anthraquinon-2-yl) Amidrazones as BCR/ABL Inhibitors;Current Computer-Aided Drug Design;2021-12

4. Synthesis and Properties of N1-(indan-5-yl)amidrazones Incorporating Piperazines and Related Congeners;Letters in Organic Chemistry;2021-01

5. Synthesis of new pyrazolo[5,1-c][1,2,4]triazines with antifungal and antibiofilm activities;Chemical Papers;2019-10-29