Synthesis and Antitumor Activity of Some N2-(Thien-3-yl)amidrazones

Author:

Abadleh Mohammed M.1,El-Abadelah Mustafa M.2,Sabri Salim S.2,Mohammed Hanan H.2,Zihlif Malek A.3,Voelter Wolfgang4

Affiliation:

1. College of Pharmacy, Taibah University, Al Madinah Almonawarrah, 41477, Saudia Arabia

2. Chemistry Department, Faculty of Science, The University of Jordan, Amman 11942, Jordan

3. Department of Pharmacology, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan

4. Interfakultäres Institut für Biochemie, Universität Tübingen, Hoppe-Seyler-Straße 4, 72076 Tübingen, Germany

Abstract

6a A set of new N2-(thien-3-yl)amidrazones (-h) incorporating N-piperazines and related congeners has been synthesized by reacting the hydrazonoyl chloride 4(derived from 3-aminothiophene- 2-carboxylate) with the appropriate sec-cyclic amine. The antitumor activity of these compounds was evaluated on breast cancer (MCF-7) and leukemic (K562) cell lines by a cell viability assay utilizing the tetrazolium dye (MTT). The amidrazone 6d encompassing the N-piperazine moiety, was the most active against MCF-7 and K562 with IC50 of 7.28 and 9:91 μM, respectively.

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

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