Spiroalkaloids and Coumarins from the Stem Bark of Pauridiantha callicarpoides

Author:

Tatuedom Ostend K.12,Kouam Simeon F.1,Yapna Diane Beatrice3,Ngadjui Bonaventure T.4,Green Ivan R.5,Choudhary M. Iqbal2,Lantovololona Jeanne E. R.6,Spiteller Michael7

Affiliation:

1. Department of Chemistry, Higher Teachers’ Training College, University of Yaounde 1, P. O. Box 47, Yaounde, Cameroon

2. H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan

3. Département des Sciences Pharmaceutiques, Faculté de Médecine et Sciences Pharmaceutiques, Université de Douala, B. P. 2701, Douala, Cameroon

4. Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, B. P. 812, Yaounde, Cameroon

5. Department of Chemistry, University of Stellenbosch, P/Bag X 1, Matieland, 7602, South Africa

6. Department of Chemistry, Laboratory of Structural Chemistry, University of Antananarivo, P. O. Box 906, 101-Antananarivo, Madagascar

7. Institute of Environmental Research (INFU) of the Faculty of Chemistry, Chair of Environmental Chemistry and Analytical Chemistry, Technical University Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany

Abstract

A new spiroalkaloid, 7-epi-javaniside (1), was isolated from the Cameroonian plant Pauridiantha callicarpoides, along with seven known compounds viz., javaniside (2), sweroside (3), hymexelsin (4), scopoletin (5), 7,7`-dihydroxy-6,6`-dimethoxy-8,8`-biscoumarin (6), 7,7`-dihydroxy-6,6`- dimethoxy-3,3`-biscoumarin (7), and 4-hydroxy-3-methoxybenzoic acid (8). The structures of the new alkaloid, as well as those of the known compounds, were elucidated by detailed spectroscopic analysis including 1D and 2D NMR and by comparison with the literature data for related compounds.

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

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