Expression of epithelial membrane antigen and cytokeratin among Indian workers exposed to cotton fibre dust in textile industries

Abstract

Background: In India, around 20 million workers are engaged in the textile industries. However, the prevalence of byssinosis has been little reported. Aims: To determine the prevalence of byssinosis and other respiratory disorders among workers exposed to cotton dust in textile mills in Delhi, India. Methods: Sputum samples were collected from 156 workers employed in 15 cotton textile mills, and expression of epithelial membrane antigen (EMA) and cytokeratin (CK) marker proteins was investigated. Information regarding respiratory symptoms, certain personal characteristics and occupational history was also gathered. Results: Symptoms were observed in 56.41% of the workers. Expression of EMA and CK was observed in 27.5% and 50% of the workers, respectively. Expression of EMA and CK was significantly associated with smoking and duration of employment. Conclusion: Measures are needed to reduce dust levels in the workplace, and to discourage smoking and alcohol consumption among the textile workers.