Geriatrik (3 Yaşlı) Erkek Ratlarda Üreme Parametrelerinin Araştırılması

Abstract

Many health problems are seen due to aging. One of these is problems in the reproductive system. Reproductive system problems are caused by lower urinary system symptoms, prostate diseases, low fertility, testicular dysfunction. The aim of this study was to compare reproductive parameters of geriatric (3 years old) and young (3 months old) rats. A 3-year-old rat is equivalent to an average 90-95-year-old human. For this purpose, sperm analysis, testicular and prostate histopathology, testicular oxidative stress parameters were examined in geriatric (3 years old) and young (3 months old) rats. In the analysis results, it was determined that sperm motility ratio decreased (p<0.001), abnormal sperm ratio increased (p<0.001) and sperm density decreased (p<0.001) in the geriatric group. Statistically, oxidative stress parameters MDA, AOPP, T-SH levels increased (p<0.05) and CAT level decreased (p<0.05) in geriatric group. Histopathologically, degeneration, necrosis and irregular alignments were observed in the tubulus seminiferous contortus in the geriatric group. Hyperplasia and dilatation of the prostate gland were detected in the geriatric group. As a result of this study, it is thought that reproductive performance in geriatric male rats is very low, and the probability of reproduction is very difficult.