Otolog Trombosit Konsantrelerinin İmmunolojik Ve Antimikrobiyal Etkileri

Abstract

Antibiotic resistance has remarkable potential in human beings and veterinary medicine. However, to prevent the clinical reflection of this resistance from reaching the feared dimensions, there is a requirement for antimicrobial treatment options supported and improved with new molecular biocursors at the preclinical point. Platelet-rich plasma (PRP) and fibrin (PRF) are biomaterial products that recently used to increase the anti-infective defense system by platelet growth factors to support postoperative wound healing, bone regeneration, graft stabilization, biofilm inhibition, catheter hygiene, and hemostasis. Recently, research has been carried out on antibacterial, antifungal, and prevention of clinical biofilm formation. Autologous platelet concentrates are autogenous and do not cause any immunological reaction or infection. Therefore, the choice and application of regenerative therapies are being favored due to their nominal invasive procedures. In particular, PRP and PRF are of interest because of their influence to stimulate and speed up the injury area healing process. Cytokines and growth factors involved in the formation of PRP are played an important role in the recovery process. This article aims to evaluate the antibacterial, antifungal and antibiofilm properties of PRP and PRF in the field of microbiology. In addition, the act of growth factors in the process of healing and their use in regenerative treatments were also evaluated.