TSH and thyroid cancer (literature analysis and results of own research)

Abstract

The aimwas to analyze the literature data on the TSH content in the blood serum of patients with differentiated thyroid carcinomas and to study the hormone content depending on the aggressiveness of the tumors, and also in the presence of some pathological changes in the extra-tumoral tissue that may affect the biological behavior of papillary carcinomas. Material and methods. A retrospective study of the cohort of patients who who had surgery for thyroid tumor. Results. The level of TSH in the serum of patients with papillary or follicular carcinomas is higher (but within the "normal" level) such in patients with nodular goiter. The highest level of hormone is recorded in the blood of women in the case of a combination of metastases in the lymph nodes with intra- and extrathyroid invasion, as well as in women over 45 with stage III/IV disease. In male patients, elevated TSH levels do not undergo significant modulations, depending on the metastatic and/or invasive properties of papillary carcinoma. The level of the hormone in the blood of women in the case of diagnosis in the extra-tumoral tissue of the gland expressed hyperplastic process or chronic thyroiditis is higher compared with patients who have not revealed pathomorphological changes in the gland tissue. Men also have an elevated level of TSH in the presence of chronic thyroiditis in the extra-tumoral tissue. When association of a tumor with adenoma or hyperplasia of the thyroid parenchyma, the content of tropic hormone does not differ from that of men from the comparison group; it is less when a single benign node or diffuse colloid goiter is present in the extra-tumoral tissue. Conclusions. In the blood of patients with thyroid carcinomas, especially in women with invasive papillary carcinomas, there is a higher level of TSH in the blood compared to that in patients with nodular goiter. The modulation of the content of trophic hormone can be affected by pathological changes in the extra-tumoral tissue that accompany the papillary carcinoma.