Cumulative incidence of hematological neoplasms and dynamic of this in different regions of the Cherkasy oblast in 1980, 1989, 2001 and 2014 years

Abstract

The purpose of the study was to analyze the cumulative incidence of hematological neoplasia and evaluate the dynamics of this in different regions of Cherkasy oblast in 1980, 1989, 2001, 2014 yy. Materials and methods. The epidemiological parameters of hematological neoplasms in the radiation-contaminated (RC), chemically contaminated (CC), radiation and chemically contaminated (RCC), conditionally clean (CNC) regions of Cherkassy oblast (CO) in 1980, 1989, 2001, 2014 yy. were analyzed. Classification of CO territories to the RC, CC, RCC, CNC regions was conducted based on reports of the dosimetry certification of all settlements of Ukraine after the Chernobyl accident and the results of determination of the level of chemical contamination by the sanitary and epidemiological service during 1980-2014 yy. Results. It was determined, that, at the limit of statistical significant (p = 0.057), on the RC territory of CO in 2001 year the relative risk for the cumulative incidence of hematologic neoplasia was on 1.41 times higher (18,682 (95 % confidence interval (CI) = 14,426 – 16,879) against 13,187 (95 % CI = 9,495 – 16,879)), compared with CNC region. In addition, in the RC territory from 1989 to 2001 year the increasing at 9,342 times (1,999 (95% CI = 0.69–3.305) versus 18,682 (95% CI = 14.426 – 16.879)) of cumulative incidence of the hematopoietic and lymphoid systems neoplasm was detected. It is proved, that in the CNC region from 2001 to 2014 year at 1,791 times (13,187 (95% CI = 9.495 – 16.879) versus 23,619 (95% CI = 18.412 – 28.826)) higher level of the cumulative incidence of hematologic neoplasia was observed. Conclusions. In the CO, which was polluted by the radiation factor because of the Chernobyl nuclear power plant accident, 5 years after that, in 2001 was detected the increasing of the relative risk of hematologic neoplasia, compared to that on the CNC region. In addition, on the RC territory from 1989 to 2001 year the increasing at 9,342 times of the incidence of hematopoietic and lymphoid system tumors was observed. This is evidence of pro-leukemic effects of ionization radiation and, probably, the increase in the diagnostic potential of the hematological service of the CO.