CHANGES IN THE LEVEL OF 25-HYDROXYVITAMIN D IN ORAL FLUID IN CHILDREN WITH PROGRESSIVE MYOPIA

Abstract

Aim. Assess the level of 25-hydroxyvitamin D in oral fluid in children with progressive myopia. Materials and methods. We examined 34 children (68 eyes) with mild myopia and 18 conditionally healthy children (36 eyes) without ophthalmological pathology. The children were divided into 2 groups: Group I (main) – 34 children (68 eyes) with mild myopia, in which subgroup Ia – 16 children (32 eyes) – with a progressive course of myopia and subgroup Ib – 18 children (36 eyes) – with a stable course of myopia. The control group consisted of 18 conditionally healthy children (36 eyes) without ophthalmological pathology. A standard ophthalmological examination was carried out: visometry, autorefractokeratometry before and after cycloplegia, biomicroscopy, ophthalmoscopy, determination of the axial length of the eye. The level of 25-hydroxyvitamin D in oral fluid was determined by the immunoenzymatic method. Results. In children with a progressive course of myopia, the indicator of 25-hydroxyvitamin D is 1,2 times lower than in children with a stable course of myopia and 2,4 times lower than in children of the control group (p<0,05). Correlation analysis showed a significant inverse relationship between the axial length of the eye and the level of 25-hydroxyvitamin D (r=–0,50,p<0,05) and between the progressive course of myopia and the level of 25-hydroxyvitamin D (r=–0,69,p<0,05). According to the ROC analysis the optimal value of the cut-off threshold for the indicator of 25-hydroxyvitamin D in oral fluid in children was ≤ 20,154 ng/ml. (sensitivity is 87,9%, specificity is 94,7%), (р <0,001). Conclusions. In children with a progressive course of myopia, the level of 25-hydroxyvitamin D is 2,4 times lower than the level of conditionally healthy children. A decrease in the level of 25 hydroxyvitamin D in the oral fluid is an additional risk factor of the progressive course of myopia in children.