The Contribution of Gene Mutations to the Pathogenesisof Tetralogy of Fallot-Reference-Cited by-同舟云学术

The Contribution of Gene Mutations to the Pathogenesisof Tetralogy of Fallot

Published:2019-06-30 Issue:2 Volume:4 Page:45-50
ISSN:2476-664X
Container-title:International Journal of Basic Science in Medicine
language:en
Short-container-title:Int J Basic Sci Med

Author:

Safari-Arababadi Amin¹²,Behjati-Ardakani Mostafa³^ORCID,Kalantar Seyed Mehdi⁴,Jaafarinia Mojtaba¹²

Affiliation:

1. Department of Molecular Genetics, Fars Science and Research Branch, Islamic Azad University, Shiraz, Iran

2. Department of Molecular Genetics, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran

3. Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

4. Genetic and Reproductive Unit, Recurrent Abortion Research Centre, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Abstract

Congenital heart disease (CHD) is considered as an important and developing area in the medical community. Since these patients can reach maturity and have children, the role of genetic determinants in increasing risk of CHD is extremely evident among children of these patients. Because genetic studies related to CHD are increasing, and each day the role of new genetic markers is more and more clarified, this review re-examined the effects of gene mutations in the pathogenesis of tetralogy of Fallot (TOF) as an important pathological model among other CHDs. Due to the complexity of heart development, it is not astonishing that numerous signaling pathways and transcription factors, and many genes are involved in pathogenesis of TOF. This review focuses on the jag1, nkx2.5, gata4, zfpm2/fog2 and cited2 genes previously reported to be involved in TOF.

Publisher

Maad Rayan Publishing Company

Reference80 articles.

1. Familial Tetralogy of Fallot caused by mutation in the jagged1 gene

2. Tetralogy of Fallot

3. Tetralogy of Fallot as a Model to Study Cardiac Progenitor Cell Migration and Differentiation During Heart Development

4. CHARGE and esophageal atresia

5. Associated cardiac anomalies in isolated and syndromic patients with tetralogy of fallot