Cancer Cells Treated by Clusters of Copper Oxide Doped Calcium Silicate-Reference-Cited by-同舟云学术

Cancer Cells Treated by Clusters of Copper Oxide Doped Calcium Silicate

Published:2019-02-21 Issue:1 Volume:9 Page:102-109
ISSN:2228-5881
Container-title:Advanced Pharmaceutical Bulletin
language:en
Short-container-title:Adv Pharm Bull

Author:

Mabrouk Mostafa¹^ORCID,Kenawy Sayed Hamed¹^ORCID,El-Bassyouni Gehan El Tabie¹^ORCID,Ibrahim Soliman Ahmed Abd El-Fattah²^ORCID,Aly Hamzawy Esmat Mahmoud³^ORCID

Affiliation:

1. Refractories, Ceramics and Building Materials Department, National Research Centre (NRC), 33 El Behooth St. Dokki- Giza, Egypt.

2. Pharmacognosy Department, Pharmaceutical and Drug Industries Division, National Research Centre (NRC), 33 El Behooth St. Dokki, Giza, Egypt.

3. Glass Research Department, National Research Centre (NRC), 33 El Behooth St. Dokki- Giza, Egypt.

Abstract

Purpose: Different compositions of copper oxide (CuO)-doped calcium silicate clusters wereused to treat the cancer cells.Methods: The influence of CuO content on the morphology, drug delivering ability,physicochemical properties and cytotoxicity was investigated.Results: The microcrystalline structure revealed the decrement of the size from (20-36 nm) to(5-7 nm) depending on the copper content percentages. Drug delivering ability of doxycyclinehyclate (Dox) was down regulated from 58% to 28%in the presence of the CuO. The inclusionof CuO and Dox didn’t show any remarkable changes on the physicochemical properties of theCuO-doped calcium silicate nanoparticles.Conclusion: The CuO-doped calcium silicate sample (5 weight %) exhibited great cytotoxicityagainst the tested cell lines compared to the CuO-free sample. CuO-doped materials displayedsignificant anticancer effect; this sheds light on its implication in the treatment of cancer.

Publisher

Maad Rayan Publishing Company

Subject

General Pharmacology, Toxicology and Pharmaceutics,Pharmaceutical Science

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