Affiliation:
1. Pharmaceutical Quality Assurance Department, Shankarrao Ursal College of Pharmaceutical Science & Research Centre Kharadi, Maharashtra, India
Abstract
This Liposomes are microscopic (unilamellar or multilamellar) vesicles. Liposomes have been considered promising and versatile drug vesicles. Compared with traditional drug delivery systems, liposomes exhibit better properties, including site-targeting, sustained or controlled release, protection of drugs from degradation and clearance, superior therapeutic effects, and lower toxic side effects. Given these merits, several liposomal drug products have been successfully approved and used in clinics over the last couple of decades. Currently, a number of liposomal formulations are on the marker for cancer treatment and many more are in pipe line. This review discusses about the liposome components, methods of preparation, drug encapsulation mechanism and the potential therapeutic applications of liposomes in cancer therapy. The term liposome means lipid body. It has been derived on the basis of name of subcellular particles, ribosome. Liposomes were first made by A.D Bangham in early 1960s. Their size ranges from 25 to 500 nm. This paper summarizes exclusively scalable techniques and focuses on limitations in respect to industrial applicability and regulatory requirements concerning liposomal drug formulations based on FDA and EMEA documents.