Hepatoprotective effect of D-Limonene Against Adriamycin Induced Hepatotoxicity in Experimental Rats

Abstract

The presence study is to evaluate hepatoprotective function of d-limonene against adraimycin induced hepatotoxicity. Monoterpenes plays an essential role to fight against various diseases. Among the various monoterpenes an efficient d-Limonene plays a fundamental role to fight against hepatotoxicity caused by cancer chemotheraphy treatment. Male albino Wistar rats were administrated with ADR (15mg/Kg body weight) in six equal injections and the protection efficacy of d-limonene (100mg/Kg body weight) was examined with reference to tissue AST level and the pathological studies was examined by microscopic study. Rats treated with ADR results in elevated level of liver AST marker enzymes, whereas the level of AST was controlled when administrated with d-Limonene. However Histopathological proof added more protective role of rats treated with d-limonene against hepatotoxicity. ADR administration of 15mg/Kg body weight of rats increase the level of hepatotoxicity by increasing the marker enzyme activity and show severe morphological changes. The final outcome from our result suggests that d-limonene (100mg/Kg body weight) a vibrant monoterpene act as latent hepatoprotective negotiator by attenuating ADR induced hepatotoxicity.