An Overview of Azide-Free methods Utilizing Tosylhydrazones for the Synthesis of 1,2,3-Triazole

Abstract

1,2,3-triazoles are nitrogen-containing heterocyclic compounds with several applications in the agrochemical and pharmaceutical sectors, which have drawn the curiosity of organic researchers in their synthesis. While traditional techniques frequently use sodium azide (NaN3) as a starting material, concerns about its toxicity and safety, have prompted researchers to develop azide-free approaches. This overview emphasizes tosylhydrazones as essential antecedents for the synthesis of 1,2,3-triazole molecules.