A study on the correlation between serumProcalcitonin level and the resistant bacterial strains isolated from meningitispatients in Bani- Suief governorate

Abstract

Absract Meningitis is an inflammation of the membranes surrounding the brain, spinal cord and the intervening cerebrospinal fluid. Bacterial Meningitis can be quite severe and may result in brain damage, hearing loss, or learning disabilities. Viral Meningitis is less severe and will clear up with specific treatment. N.meningitides, S. pneumonia, H. influenza , M. tuberculosis are among the commonest bacterial causes.This study aimed to assess the diagnostic role of cerebrospinal LDH and serum procalcitonin (PCT-Q) in meningitis in Bani- suef governorate and to differentiate bacterial from viral meningitis. Patients were classified cases into three groups; group (I) for septic meningitis, group (II) for aseptic meningitis and group (III) for meningism along with 100 control patients. After clinical examination, CBC, ESR, CRP, blood sugar level, renal and hepatic functions. CSF LDH, serum PCT were assessed in some patients. CSF LDH was higher than normal in 100% of patients suffering from septic meningitis and in 98% of patients suffering from aseptic meningitis. Serum PCT was positive in all patients with septic meningitis whereas it was negative in 69(66%) patients. There is a correlation between elevated serum levels of PCT and presence of bacterial resistant strains in cases of septic meningitis.