Comparison of Dose Distribution to Target Volume and Organs at Risk using 3D CRT, IMRT, and VMAT Techniques in Glioblastoma Cases

Abstract

The average lifetime risk of secondary cancer after irradiating glioblastoma radiation therapy to healthy organs shows that the technique of volumetric modulated arc therapy (VMAT) has a smaller risk of developing secondary cancer compared to intensity modulated radiation therapy (IMRT) and three-dimensional radiation therapy (3DCRT). Parameters of dose distribution, namely the target volume and dose received by the organs at risk (OAR), are used to compare these three techniques. The distribution of doses from TPS results in the form of DVH and isodose in the 3D CRT, IMRT, and VMAT techniques shows that the distribution of doses to healthy organs around the glioblastoma irradiation area is in the safe category and is still within tolerance limits. With VMAT, the PTV and CTV dose results were more optimal compared to the 3D CRT and IMRT techniques. 3D CRT showed a PTV dose value of 5551.8 cGy and a CTV of 5515.3 cGy. IMRT shows a PTV dose value of 6035.0 cGy and a CTV of 6018.8 cGy. VMAT shows PTV dose values of 6101.8 cGy and CTV of 6044.7 cGy. It can be seen that the distribution of doses to healthy organs in general in the VMAT technique is more optimal than the IMRT and 3D CRT techniques in protecting OAR.