Affiliation:
1. Department of Chemistry, Smt. J. A. Patel Mahila College, Morbi, Gujarat, India
Abstract
An effectual direct synthesis of 1,4-dihydropyrimido[1,2-a]benzimidazole (C-01 to C-10) was developed from 1H-benzo[d]imidazol-2-amine, 4-(benzyloxy)-3-methoxybenzaldehyde, N-(substituted phenyl)-3-oxobutanamide by adding few drop of DMF and in presence of conc.HCL. The product was obtained after about 5 hours of heating in refluxing condition. The synthesized compounds were characterized by different spectral and elemental analysis. Some of the obtained compounds showed a promising antimicrobial activity on screening against Gram-positive and Gram-negative bacterial strains.