Evaluation of the Antimicrobial Activities of Some Metal (Ii) Pyrimethamine Complexes

Abstract

The research work focused on the synthesis and antimicrobial studies of complexes of Manganese (II), Cobalt (II) and Nickel (II) with 5-(-4-Chlorophenyl)-6ethylpyrimidinediamiane (pyrimethamine) which serve as ligand. The complexes were prepared by direct combination of aqueous solution of the metal ions with the solution of pyrimethamine drug in methanol. The metal complexes were then characterized by conductance measurement, determination of decomposition temperature and infrared spectral analysis. The spectral analysis shows the ligand as bidental and coordinates to the metals through the nitrogen atom of the respective amine groups. Elemental analysis shows that all the complexes have octahedral configuration [ML2CL2], Where L = Ligand and M = metal. Molar conductance measurement and decomposition temperature analysis indicate that all the complexes are stable, non-electrolytes chelates. Antimicrobial evaluation of the complexes shows varied degree of inhibitory effect against some bacterial and fungal isolates; staphylococcus aureus, escheria coli, salmonella typhi and mucor spp and Rhizopus spp. However the antimicrobial activity of Mn(II) complex was found to be greater than cobalt (II) and Nickel (II) Complexes.