Affiliation:
1. Hiranandani Foundation School Powai, Mumbai, Maharashtra, India
Abstract
Neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), and spinocerebellar ataxias (SCAs), pose a significant medical, social, financial, and scientific challenge. Recent data suggests that many of these illnesses have aberrant neuronal calcium (Ca2+) transmission. Normal aging causes alterations in neuronal Ca2+ signaling that are similar but less drastic. Here, we address the dysregulation of calcium in a number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Also noted is the potential effectiveness of Ca2+ blockers in the treatment of various illnesses.