Affiliation:
1. Department of Chemistry, Dada Patil Mahavidyalaya, Karjat, Ahmednagar, Maharashtra, India
Abstract
A simple, convenient, and environmentally friendly method for the synthesis of 1,3-oxazine derivatives has been developed under aqueous conditions. The reaction proceeds via one pot multicomponent condensation of ? or ?- naphthol, aromatic aniline and formaldehyde using polyphosphoric acid as green catalyst. The current protocols are simple, requires less reaction time and provides high yields. Non-polluting synthetic procedures are used to avoid harmful effects of organic solvents on the environment.
Reference55 articles.
1. P. Laszlo, Organic Reaction: Simplicity and Logic, Wiley New York, (1995).
2. T. Tanaka, F. Toda Solvent-free Organic Synthesis, Chem, Rev.100, 1025-1074, (2000).
3. M. Alam, R. Varala, S.R. AdapaSynlett, 67-70, (2003).
4. A. Dondi, A. Massi, E. Minghini, S. Sabbatini, V. Bertoasi J. Org. Chem,68, 6172-6183, (2003).
5. R. Hanselmann, J. C. Zhou, P. Ma, P. N. Confalone J. Org. Chem,68, 8739-8741, (2003).