Association Between Sleep Time and Pro- and Anti-Inflammatory Biomarkers Is Mediated by Abdominal Obesity Among Adolescents-Reference-Cited by-同舟云学术

Association Between Sleep Time and Pro- and Anti-Inflammatory Biomarkers Is Mediated by Abdominal Obesity Among Adolescents

Published:2023-10-01 Issue:10 Volume:20 Page:926-933
ISSN:1543-3080
Container-title:Journal of Physical Activity and Health
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Author:

De Moraes Augusto César Ferreira¹²³^ORCID,Medeiros-Oliveira Vanessa Cassia²³^ORCID,Burford Katie¹^ORCID,Schaan Beatriz D.⁴⁵⁶^ORCID,Bloch Katia⁷^ORCID,de Carvalho Kênia Mara Baiocchi⁸^ORCID,Cureau Felipe Vogt⁹^ORCID,Nascimento-Ferreira Marcus Vinicius³¹⁰^ORCID

Affiliation:

1. The University of Texas Health Science Center at Houston School of Public Health Austin Campus, Department of Epidemiology, Human Genetics, and Environmental Science, Michael & Susan Dell Center for Healthy Living, Austin, TX, USA

2. Department of Epidemiology, Graduate Program in Public Health and Graduate Program in Epidemiology, School of Public Health, University of Sao Paulo, Sao Paulo, SP, Brazil

3. YCARE (Youth/Child and cArdiovascular Risk and Environmental) Research Group, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil

4. Faculty of Medicine, Graduate Program in Cardiology and Cardiovascular Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

5. Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil

6. Faculty of Medicine, Graduate Program in Endocrinology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

7. Instituto de Estudos em Saúde Coletiva, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

8. Graduate Program in Human Nutrition, Universidade de Brasília, Brazil

9. Graduate Program in Cardiology and Cardiovascular Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

10. HEALth, pHYsical activity and Behavior ReseArch (HEALTHY-BRA) group, Federal University of Tocantins, Campus Miracema, Miracema, TO, Brazil

Abstract

Objectives: Movement behaviors and abdominal obesity are associated with higher inflammatory biomarkers. However, the role of waist circumference as a mediating factor is still unknown. Thus, our aims were to (1) test the associations between 24-hour movement behavior variables (physical activity, sedentary behavior, and sleep), abdominal obesity, and pro- and anti-inflammatory biomarkers; and (2) investigate whether abdominal obesity had a mediating effect between the investigated associations. Methods: This multicenter cross-sectional study included 3591 adolescents (aged 12–17 y) from 4 Brazilian cities. Waist circumference (in centimeters; at half the distance between the iliac crest and at the lower costal margin), 24-hour movement behaviors (validated questionnaire), high-sensitive C-reactive protein, and adiponectin (serum plasma) were evaluated. We used multiple mediation regression models (95% confidence interval) to determine if waist circumference mediated the association between 24-hour movement behaviors and pro- and anti-inflammatory biomarkers. Results: The results revealed that screen time and moderate to vigorous physical activity were not associated with pro- or anti-inflammatory biomarkers. However, sleep duration (in hours per day) was negatively associated with pro- (C-reactive protein, β = −0.08; 95% confidence interval, −0.38 to −0.02) and anti- (adiponectin, β = −0.31; 95% confidence interval, −2.13 to −0.12) inflammatory biomarkers. Our results also showed that waist circumference mediated the association between sleep duration and high-sensitive C-reactive protein (2.7%), and adiponectin (2.8%). Conclusion: Sleep duration was inversely associated with pro- and anti-inflammatory biomarkers, and these relations were mediated by abdominal obesity. Therefore, adolescents having healthy sleep can have implications for reducing waist circumference and inflammatory indicators.

Publisher

Human Kinetics

Subject

Orthopedics and Sports Medicine,Epidemiology,Public Health, Environmental and Occupational Health,Physical Therapy, Sports Therapy and Rehabilitation

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