The Association Between Allostatic Load and Frailty Trajectories Among Adults Aged 50+ Years: Mediating Role of Physical Activity

Author:

Shi Kanglin1,He Lingxiao123,Zhang Zeyun1,Lin Jianlin1,Chen Xiaodong1,Du Xinyuan1,Shi Kewei1,Yang Jinzhu1,Shi Zaixing123,Fang Ya123ORCID

Affiliation:

1. School of Public Health, Xiamen University, Xiamen, China

2. State Key Laboratory of Molecular Diagnostics and Molecular Vaccinology, Xiamen, China

3. Key Laboratory of Health Technology Assessment of Fujian Province, School of Public Health, Xiamen University, Xiamen, China

Abstract

Objectives: To identify frailty trajectories and examine its association with allostatic load (AL) and mediating effect of physical activity (PA). Methods: This study included 8,082 adults from the English Longitudinal Study of Aging over Waves 4–9. AL was calculated by 14 biological indicators, and a 53-item frailty index was used to evaluate frailty. Frailty trajectories were classified by group-based trajectory modeling, and the mediated effect of PA was tested by causal mediation analysis. Results: Four frailty trajectories were identified: “Robustness” (n = 4,437, 54.9%), “Incident prefrailty” (n = 2,061, 25.5%), “Prefrailty to frailty” (n = 1,136, 14.1%), and “Frailty to severe frailty” (n = 448, 5.5%). High baseline AL was associated with increased odds of “Incident prefrailty,” “Prefrailty to frailty,” and “Frailty to severe frailty” trajectories. PA demonstrated significant mediated effects in aforementioned associations. Conclusions: AL is significantly associated with the onset and progression of frailty, and such associations are partially mediated by PA.

Publisher

Human Kinetics

Subject

Geriatrics and Gerontology,Gerontology,Rehabilitation,Physical Therapy, Sports Therapy and Rehabilitation

Reference52 articles.

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