The Human Genome, Physical Activity, Fitness, and Health

Author:

Bouchard Claude1

Affiliation:

1. Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA

Abstract

A summary of the evidence for a contribution of genetic variability to physical activity–related traits is presented. The availability of a reference human DNA sequence has made it possible to screen individuals and populations for the presence of genomic differences. Even though more than 100 million DNA variants have been identified, human beings share a genomic sequence, which is more than 99% identical. Four major lessons can be derived from ongoing genomic and genetic studies. First, the connection between a genotype and a phenotype is highly complex. Second, the expression of genes is regulated via multiple interacting mechanisms. Third, redundancy and compensatory mechanisms are ubiquitous. Fourth, complex, multifactorial traits are influenced by polygenic systems defined by hundreds and thousands of loci with most alleles characterized by very small effect sizes. The contribution of genetic variability is briefly summarized for human longevity, common chronic diseases, physical activity level, cardiorespiratory fitness in the sedentary state, and in response to exercise programs.

Publisher

Human Kinetics

Subject

Public Health, Environmental and Occupational Health,Physical Therapy, Sports Therapy and Rehabilitation

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3