SKIN MICROBIOTA AND ITS INTERPLAY WITH WOUND AND BURN HEALING: IMPACT OF EPITHELIAL BIOREGENERATOR

Abstract

The skin microbiota is intimately coupled with cutaneous health and disease. Interactions between commensal microbiota and the multiple cell types involved in cutaneous wound healing regulate the immune response and promote barrier restoration. This dialog between host cells and the microbiome is dysregulated in chronic wounds and burns. To investigate whether changes in composition were present in the skin microbiome of individuals at risk of developing these lesions. Colonization of the wound and burn with commensal bacteria may promote wound and burn healing by inducing antimicrobial proteins such as Perforin-2, thus stimulating a protective immune response against pathogenic bacteria. Wound and burn infection with pathogenic bacteria results in Perforin-2 suppression in both hematopoietic and nonhematopoietic cells and inhibition of healing. A new study now shows that, in most cases, the causative agents of these infections are bacteria from the patient's own skin. For this reason, authors investigated the impact of Epithelial Bioregenerator to eliminate microorganisms from the chronic wounds and burns.