Author:
A. ALI Mahmoud, ,CIOBICA Alin,
Abstract
Recently gut microbiome, genetics, and epigenetics have been incresingly cited for being involved in aging and longevity. In addition, the oxidative stress status also has a significant role in the context of aging and longevity, where also lipofuscin take place and become a hallmark of aging. Thus, in this mini-review we highlighted the role of the gut microbiome in aging and longevity, and its relationship with antioxidants in the prevention of age-related diseases. We also discussed the possible mechanistical aspect for the interactions between lipofuscin, oxidative stress, and aging, and we reveal additionally a new theory of aging based on the complex interactions among genetics, microbiome, environment, aging and longevity.
Publisher
Academia Oamenilor de Stiinta din Romania
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