Abstract
AbstractThe feasibility of using an external beam microprobe facility to explore the biological effects generated by proton irradiation in cultured cells is demonstrated. An in-air irradiation set-up was developed that allows energy tuning and enables estimating the flux and dose deposition in cells. A pilot study on the effect of boron-rich metallacarboranes as radiosensitizers towards human glioblastoma cells was carried out. This served as a proof of concept for the enhancement effect of proton irradiation induced by the presence of boron, which undergoes a nuclear 11B(p,α)αα reaction. Details of the experimental set-up and physical parameters measured are presented. Also, preliminary results of cell’s irradiation and uncertainties are discussed anticipating the advances that have been achieved by our group in this field.
Funder
Fundação para a Ciência e a Tecnologia
Generalitat de catalunya
Ministerio de Economia y Competitividad Gobierno Espana
Publisher
Springer Science and Business Media LLC
Reference16 articles.
1. García-Mendiola T, Bayon-Pizarro V, Zaulet A, Fuentes I, Pariente F, Teixidor F, Viñas C, Lorenzo E. Metallacarboranes as tunable redox potential electrochemical indicators for screening of gene mutation. Chem Sci. 2016;7:5786–97.
2. Yoon D-K, Jung J-Y, Suha TS. Application of proton boron fusion reaction to radiation therapy: a Monte Carlo simulation study. Appl Phys Lett. 2014;105:223507.
3. Moreau DC. Potentiality of the proton-boron fuel for controlled thermonuclear fusion. Nucl Fusion. 1977;17:13–20.
4. Spraker MC, Ahmed MW, Blackston MA, Brown N, France RH III, Henshaw SS, Perdue BA, Prior RM, Seo P-N, Stave S, Weller HR. The 11B(p,α)8Be $\to \alpha + \alpha $ and the 11B(α,α)11B reactions at energies below 5.4 MeV. J Fusion Energy. 2012;31:357–67.
5. Ruggiero AG. Nuclear Fusion of Protons with Boron. Contribution to Conference on Prospects for Heavy Ion Inertial Fusion, Aghia Pelaghia, Crete, Greece, September 26–October 1 (1992). https://inis.iaea.org/collection/NCLCollectionStore/_Public/24/028/24028563.pdf (accessed 9-6-2022).
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献