Regulating life after death: how mechanical communication mediates the epithelial response to apoptosis

Author:

Bonfim-Melo AlexisORCID,Duszyc Kinga,Gomez Guillermo A.,Yap Alpha S.ORCID

Abstract

Abstract It is increasingly evident that cells in tissues and organs can communicate with one another using mechanical forces. Such mechanical signalling can serve as a basis for the assembly of cellular communities. For this to occur, there must be local instabilities in tissue mechanics that are the source of the signals, and mechanisms for changes in mechanical force to be transmitted and detected within tissues. In this review, we discuss these principles using the example of cell death by apoptosis, when it occurs in epithelia. This elicits the phenomenon of apical extrusion, which can rapidly eliminate apoptotic cells by expelling them from the epithelium. Apoptotic extrusion requires that epithelial cells detect the presence of nearby apoptotic cells, something which can be elicited by the mechanotransduction of tensile instabilities caused by the apoptotic cell. We discuss the central role that adherens junctions can play in the transmission and detection of mechanical signals from apoptotic cells. Graphical abstract

Funder

National Health and Medical Research Council

Australian Research Council

Centre of Excellence in Cognition and its Disorders, Australian Research Council

Publisher

Springer Science and Business Media LLC

Subject

Surfaces and Interfaces,General Materials Science,General Chemistry,Biophysics,Biotechnology

Reference63 articles.

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