A novel methodology for the diffusion coefficient determination in porous media by X-ray high-resolution radiographies

Author:

Santini M.ORCID,Fest-Santini S.,Cossali G. E.,Casatta N.,Lupo C.

Abstract

AbstractThe first step in diagnosing a patient with cancer is the biopsy and the study of the tissue sample taken, suitably processed, is essential for a correct diagnosis. Tissue processors are machines that automatically perform the entire processing protocol, often relying on empirical timing related to chemical diffusions in the biological samples. The determination of the diffusion coefficient in porous materials, such as histological tissue, is still under study with multiple methods often resulting in inaccurate predictions and with few amounts of literature data for biological samples. The authors present an experimental technique, based on a multitude of X-ray radiographs acquired over time, where the intensity of the attenuation to the ionising beam is proportional to the concentration of the solvent that diffuses in the histological preparation. The paper so describes a proof-of-concept of a novel method to estimate the diffusion coefficient in a histological sample, based on the acquisition of time-dependent X-ray radiographs and the solution of an inverse diffusion problem.

Funder

PNC

Università degli studi di Bergamo

Publisher

Springer Science and Business Media LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3