Review on Nano-Emulsion Drug Delivery System and Formulation, Evaluation and Their Pharmaceutical Applications

Abstract

Nano-emulsion drug delivery system such as develop to eliminate the limitations with traditional drug administration system. This review provided a good overview of the recent advances in the Nano-emulsion drug delivery system. These are nano-sized submicron emulsions developed to enhanced the circulates of active pharmaceutical ingredients to targeted site. Nano-emulsion is a homogeneous mixture of lipid and aqueous phase and stabilization is obtained through the use of an effective substance such as emulsifying agents. The droplet size has been range between the 50-500 nm. The size and shape of the substance distributed throughout the usual process differentiates of emulsion, micro-emulsion, and nano-emulsion. Nano-emulsion gives a novel dosage form for less water solubility drugs and increases pharmacological activity of drugs. Nano-emulsion is used in the future cosmetic industry, diagnostic testing, drug treatment, and biotechnology. This analysis aims to include brief information on the nano-emulsion, advantages, disadvantages, limitations of nano-emulsion, types of nano-emulsion, components of formulations, surface active agents (Surfactant), preparation methods, characterization methods with strong attention of different pharmaceutical applications of nano-emulsion in a different area such as cancer and tumors therapy, targeted drug delivery, mucosal vaccine, trans-dermal drug delivery system.