ACUTE MYELOID LEUKEMIA;

Abstract

Background: Acute myeloid leukemia (AML) is an aggressive haematologicalmalignancy with highest incidence in older adults. AML accounts for approximately 25% of allleukemias in adults in the Western world, and therefore is the most frequent form of leukemia.Objective: The aim of study was to analyze the demographic and clinical features and frequencyof various subtypes of acute myeloid leukemia in adult age group in our population. Studydesign: Descriptive Cross sectional survey. Settings: The study was conducted in PathologyDepartment, King Edward Medical University, Lahore. Study Period: Five years September2007 to September 2011. Material and Methods: A five year data of patients diagnosed asacute myeloid leukemia was collected from September 2007 to September 2011 in PathologyDepartment, King Edward Medical University, Lahore. Patients on chemotherapy andradiotherapy were excluded from the study. Results: Among the 77 patients of Acute MyeloidLeukemia, Acute myeloid leukemia with maturation AML M2 (37.7%) was the most commonsubtype and the least common was Acute megakaryoblastic leukemia AML M7 (1.3%).Meanage for AML was 28 years (Range 15-75 years). M:F ratio was 1.5:1. Fever was found be the mostfrequent presenting feature followed by pallor, bleeding and gum hypertrophy in the descendingorder. More than 50% patients presented with hepatosplenomegaly. Lymphadenopathy wasseen in 30% of patients. Mean peripheral blood blast count was 29%. 12 patients (15.5%)presented with pancytopenia. Conclusion: The study showed male predominance in Acutemyeloid leukemia with mean age of 28 years and the most common subtype was AML- M2.