Author:
KORKMAZ SERHAT,Demirel Emin
Abstract
Background: In this study, we aimed to examine the success of temporal muscle thickness (TMT) and masseter muscle thickness (MMT) in predicting overall survival (OS) in primary IDH-wild glioblastoma (GBM) patients with and without MGMT promoter hypermethylation through publicly available datasets.
Methods: We included 345 primary IDH-wild GBM patients with known MGMT promoter hypermethylation status who underwent gross-total resection and standard treatment, whose data were obtained from the open datasets. TMT was evaluated on axial thin section postcontrast T1-weighted images, and MMT was evaluated on axial T2-weighted images. The median TMT and MMT were used to determine the cut-off point.
Results: The findings showed that median TMT 9.5 mm and median MMT 12.7 mm determined the cut-off value in predicting survival. Both TMT and MMT values less than the median muscle thickness were negatively associated with OS (TMT<9.5: HR 3.63 CI 2.34–4.23, p <0.001, MMT<12.7: HR 3.53 CI 2.27–4.07, p <0.001). When patients were classified according to MGMT positivity, the findings showed MGMT-negative patients (TMT<9.5: HR 2.54 CI 1.89–3.56, p <0.001, MMT<12.7: HR 2.65 CI 2.07–3.62, p <0.001) and MGMT-positive patients (TMT<9.5: HR 3.84 CI 2.48–4.28, p <0.001, MMT<12.7: HR 3.73 CI 2.98–4.71, p <0.001).
Conclusion: Both TMT and MMT successfully predict survival in primary GBM patients. In addition, it can successfully predict survival in patients with and without MGMT promoter hypermethylation.
Publisher
ASEAN Neurological Association
Subject
Neurology (clinical),Neurology
Cited by
1 articles.
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