Author:
Costa Ana Carolina Messias de Souza Ferreira da,Moreira Marcela Brennand Pina,Cahú Amina Kadja Martins,Romeiro Edenilze Teles,Cavalcanti Rafael Luiz Pinheiro,Pontes Melissa Barbosa,Sousa João Vinícius Silva,Tomais Leticia Nery da Silva,Figueiredo José Glauber Oliveira
Abstract
Objective: To assess if GSTT1 and GSTM1 null polymorphisms increase susceptibility to colorectal cancer. Methods: A search was conducted in PubMed, SciELO, BVS, and Medline databases. Forty articles were selected, totaling 12,698 cases and 19,517 controls. Odds ratios with 95% confidence intervals were used, and p-values <0.05 were considered significant. The Dersimonian-Laird method was applied for p-values <0.05, and the Mantel-Haenszel method was used otherwise. All p-values were two-tailed with an alpha value of 0.05 determined a priori. STATA 16.0 software was utilized. Result: A higher risk of colorectal cancer was shown in the general population for the GSTM1 null genotype (OR=1.11; 95%CI [1.03, 1.19]; P<0.01). No significant risk was observed for GSTT1 or the GSTM1/GSTT1 null combination (OR=1.09; 95%CI [0.98, 1.22]; P<0.01 and OR=1.13; 95%CI [0.89, 1.43]; P<0.01, respectively). In subgroup analysis, increased colorectal cancer risk was found for Asians with the GSTM1 null genotype (OR=1.10; 95%CI [1.02, 1.20]; P=0.02) and GSTM1/GSTT1 null combination (OR=1.49; 95%CI [1.03, 2.15]; P<0.01). Conclusion: The findings suggest that the GSTM1 null polymorphism and the GSTM1/GSTT1 null combination are potential susceptibility factors for colorectal cancer, particularly in the Asian population.
Publisher
South Florida Publishing LLC