Effects of gentaminoseleferon on blood parameters during treatment of Mycoplasma dispar respiratory infection in calves
-
Published:2020
Issue:10
Volume:13
Page:2197-2202
-
ISSN:2231-0916
-
Container-title:October-2020
-
language:en
-
Short-container-title:Vet World
Author:
Abed Alhussen Mohammad1ORCID, Naef Hamdan1ORCID, Vatnikov Yury Anatolyevich1ORCID
Affiliation:
1. Department of Veterinary Medicine, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow 117198, Russian Federation.
Abstract
Background and Aim: Respiratory diseases in young cattle are among the significant cattle pathologies that cause considerable economic damage globally. For the treatment of respiratory diseases, coformulated drugs that increase general nonspecific resistance, exhibit adaptogenic and anti-inflammatory properties, and normalize metabolic processes in animals are currently being used. The aim of our study was to investigate the therapeutic efficacy of the complex drug "gentaminoseleferon", used in the treatment of respiratory diseases in calves, especially in Mycoplasma dispar infection.
Materials and Methods: The animals were divided into three groups. Calves with the first clinical signs of respiratory pathology were randomly divided into two groups. The first experimental group (n=5) was intramuscularly injected with sulfetrisan at a dose of 5-10 mL/animal once per day for 7 days. The second experimental group (n=5) was given gentaminoseleferon at a dose of 1 mL/10 kg of body weight once per day for 7 days. The drugs were not used in the control group, the "healthy animals (n=5)". Blood samples were taken 10 days before and after treatment and compared between the experimental and healthy calves. The changes in the hematological and biochemical parameters of blood and serum were evaluated.
Results: During the recovery process of animals in the experimental groups, a normalization of the hematological and biochemical parameters of blood and serum was noted. Interestingly, in calves of the second experimental group, an increase in the total serum protein content by 2.2% (p<0.05) was recorded in comparison with the first group. The second group, furthermore, showed an increase in Vitamins A, E, and C concentrations by 13.5% (p<0.05), 11.9% (p<0.005), and 15.1% (p<0.0005), respectively, as well as in zinc and iron concentrations by 4.1% (p<0.05) and 9.3% (p<0.0001), respectively. These findings indicate a more pronounced decrease in the inflammatory process in the respiratory system and intensive restoration of metabolism, thereby establishing the high therapeutic efficacy of gentaminoseleferon.
Conclusion: Gentaminoseleferon was proven highly effective in the treatment of calves with respiratory illnesses and in restoring homeostasis in the organisms of animals after treatment, as indicated by the normalization of morphological and biochemical blood parameters with a reduction in the recovery time.
Funder
Ministry of Education and Science of the Russian Federation
Publisher
Veterinary World
Subject
General Veterinary
Reference31 articles.
1. Murray, G.M., More, S.J., Clegg, T.A., Earley, B., O’Neill, R.G., Johnston, D., Gilmore, J., Nosov, M., McElroy, M.C., Inzana, T.J. and Cassidy, J.P. (2018) Risk factors associated with exposure to bovine respiratory disease pathogens during the peri-weaning period in dairy bull calves. BMC Vet. Res., 14(1): 53. 2. Constable, P., Hinchcliff, K.W., Done, S. and Gruenberg, W. (2016) Veterinary Medicine: A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats Two-Volume Set. Saunders Ltd., England. 3. Taylor, J.D., Fulton, R.W., Lehenbauer, T.W., Step, D.L. and Confer, A.W. (2010) The epidemiology of bovine respiratory disease: What is the evidence for predisposing factors? Can. Vet. J., 51(10): 1095-1102. 4. Dubrovsky, S.A., Van Eenennaam, A.L., Karle, B.M., Rossitto, P.V., Lehenbauer, T.W. and Aly, S.S. (2019) Epidemiology of bovine respiratory disease (BRD) in preweaned calves on California dairies: The BRD 10K study. J. Dairy Sci., 102(8): 7306-7319. 5. Louie, A.P., Rowe, J.D., Love, W.J., Lehenbauer, T.W. and Aly, S.S. (2018) Effect of the environment on the risk of respiratory disease in preweaning dairy calves during summer months. J. Dairy Sci., 101(11): 10230-10247.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|