Royal Jelly and Aliskiren mutually annul their protective effects against gentamicin-induced nephrotoxicity in rats
-
Published:2020
Issue:12
Volume:13
Page:2658-2662
-
ISSN:2231-0916
-
Container-title:Veterinary World
-
language:en
-
Short-container-title:Vet World
Affiliation:
1. Department of Pharmacy, Faculty of Pharmacy, Middle East University, Amman, Jordan.
Abstract
Background and Aim: Gentamicin (GM) is one of the most effective antibiotics for severe, life-threatening Gram-negative infections. Nevertheless, its clinical use has been restrained because of its nephrotoxic potential. Royal jelly (RJ) and aliskiren (ALK) can individually prevent such toxic effects. The aim of this study was to explore the protective effects of a combination treatment of RJ and ALK on GM-mediated nephrotoxicity.
Materials and Methods: Thirty-two adult female Wistar rats were divided equally into four groups: (I) Receiving normal saline; (II) GM (100 mg/kg, intraperitoneal [i.p.] injection); (III) GM (100 mg/kg, i.p. injection) plus ALK (50 mg/kg, i.p. injection); and (IV) GM (100 mg/kg, i.p. injection) plus ALK (50 mg/kg, i.p. injection) in combination with RJ (150 mg/ kg, orally). All treatments were administered daily for 10 days. The blood levels of creatinine, urea, uric acid, albumin, and total protein were measured. Then, the animals were sacrificed, and the kidneys were taken for histopathology.
Results: Compared to normal control rats, GM-injected rats showed significantly (p<0.001) higher serum concentrations of uric acid, urea, and creatinine as well as evidently (p<0.001) lower blood levels of albumin and total protein. Moreover, GM administration was associated with significant renal histopathological changes. All these alterations were considerably (p<0.05) improved in GM-injected rats receiving ALK compared to rats receiving GM alone. However, when RJ was given in combination with ALK to GM-injected rats, it lessened the beneficial nephroprotective effects of both agents.
Conclusion: The combination treatment of RJ and ALK is not desirable for GM-induced nephrotoxicity. Further studies are crucial to accurately explore the precise mechanism of RJ antagonistic interaction with ALK.
Funder
Middle East University
Publisher
Veterinary World
Subject
General Veterinary
Reference35 articles.
1. Kaplan, H.M., Şingirik, E., Erdoğan, K.E. and Doran, F. (2017) Protective effect of alpha-linolenic acid on gentamicin-induced ototoxicity in mice. Somatosens. Mot. Res., 34(3): 145-150. 2. Arjinajarn, P., Chueakula, N., Pongchaidecha, A., Jaikumkao, K., Chatsudthipong, V., Mahatheeranont, S., Norkaew, O., Chattipakorn, N. and Lungkaphin, A. (2017) Anthocyanin-rich riceberry bran extract attenuates gentamicin-induced hepatotoxicity by reducing oxidative stress, inflammation and apoptosis in rats. Biomed. Pharmacother., 92: 9412-420. 3. Chen, Q., Cui, Y., Ding, G., Jia, Z., Zhang, Y., Zhang, A. and Huang, S. (2017) PEA3 protects against gentamicin nephrotoxicity: Role of mitochondrial dysfunction. Am. J. Transl. Res., 9(5): 2153-2163. 4. Mahi-Birjand, M., Yaghoubi, S., Abdollahpour-Alitappeh, M., Keshtkaran, Z., Bagheri, N., Pirouzi, A., Khatami, M., Sepehr, K.S., Peymani, P. and Karimzadeh, I. (2020) Protective effects of pharmacological agents against aminoglycoside-induced nephrotoxicity: A systematic review. Expert Opin. Drug Saf., 19(2): 167-186. 5. Dursun, M., Sahin, S., Besiroglu, H., Otunctemur, A., Ozbek, E., Cakir, S.S., Cekmen, M. and Somay, A. (2018) Protective effect of nebivolol on gentamicin-induced nephrotoxicity in rats. Bratisl. Lek. Listy, 119(11): 718-725.
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|