The Effect of Cerebral White Matter Lesions on Walking Time & Vascular Risk Factors

Abstract

Introduction: White matter lesions are common neurological diseases in the elderly. In this study, we aimed to investigate the impact of cerebral white matter lesions on walking time and daily living activities in the elderly population. Methods: A total of 82 individuals, including 40 healthy volunteers and 42 age and sex-matched patients, were enrolled in this study. Magnetic resonance imaging findings were recorded based on the Fazekas Staging System. Risk factors potentially predisposing individuals to white matter lesions were documented through laboratory testing. Additionally, atherothrombotic plaque formations and stenosis were graded using Carotid and Vertebral Artery Doppler Ultrasonography in patients with white matter lesions. The Lawton Instrumental Activities of Daily Living Scale, Mini-Mental State Examination, and the Timed Up & Go Test were administered to both the patient and control groups to assess daily living activities and cognitive functions. Results: The results of this research showed that as the percentage of stenosis increased in Carotid and Vertebral Artery Doppler Ultrasonography, there were corresponding decreases in Lawton Instrumental Activities of Daily Living Scale scores, haemoglobin and hematocrit values while fasting blood glucose and homocysteine levels increased as expected. Furthermore, significant differences were observed in the Timed Up & Go Test in advanced stages when evaluated according to the Fazekas Staging System. Conclusion: Our study indicated that white matter lesions do not significantly affect daily living activities but prolong the walking time in elderly individuals.