Clinical And Genetic Risk Factors For Asthma Exacerbations And Mortality In Adults

Abstract

Background — According to epidemiological studies, nearly 7 million people in Russia suffer from bronchial asthma (BA), of which 1 million have a severe form of the disease that is difficult to control. Insufficiently effective control of BA leads to a reduction in the quality of life, the development of its more severe forms, an increase in the frequency of exacerbations of the disease, and an increase in the number of disability and death cases in patients. Objective — The goal of our research was conducting a long-term cohort study of BA in adults living in the Republic of Bashkortostan and assessing the clinical and prognostic value of internal and external risk factors for exacerbation and death from BA. Methods and Results — We analyzed the medical records of 213 BA patients 18 to 67 years а age from 2012 through 2022. Genotyping of six SNPs in ADRB2 (rs1042713, rs1042714), CRHR1 (rs242939, rs1876828), NR3C1 (rs41423247), and HRH3 (rs3787429) genes was performed by real-time polymerase chain reaction. Using regression analysis, we assessed predictors of the risks of exacerbation and death in BA and built multivariate models for each outcome. Conclusion — As a result of regression analysis, significant clinical and prognostic risk factors for re-exacerbation and death from BA were identified.